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教师简介

蓝柯
时间:2017-02-22 15:44:05 阅读量:
 
     职称职务:教授、主任
Appointment: Professor, Director
学科专业:病毒学
Department: Virology
研究方向:肿瘤病毒感染与致瘤机制
Research: Mechanisms of  Tumor Viral Infection and Pathogenesis
实验室位置:生命科学学院大楼4105房间
Location: College of Life Sciences, Room 4105 
联系方式:
Email: klan@whu.edu.cn

 

教育经历/Education:
1989-1994  重庆医科大学临床医学专业,获医学学士学位
1995-1998  重庆医科大学病理生理学专业,获医学硕士学位
1998-2001  中南大学湘雅医学院病理生理学专业,获医学博士学位

工作经历与任职/Professional Experience:
1994-1995  四川省屏山县人民医院,住院医师
2002-2006  美国宾夕法尼亚大学医学院,博士后
2006-2016  中国科学院上海巴斯德研究所研究员,博士生导师,肿瘤病毒研究组组长,病原诊断技术研发中心主任
2011-2016  中国科学院上海巴斯德研究所副所长,纪委书记
2017-至今   武汉大学病毒学国家重点实验室主任,生命科学学院教授、博士生导师

学术兼职:
中国病理生理学会肿瘤专业委员会常委
中国微生物学会病毒专业委员会理事
Journal of Virology编委
Journal of Medical Virology副主编

获奖及荣誉:
国家万人计划领军人才(2016年)
上海市先进工作者(2015年)
上海领军人才(2015年)
国家创新人才推进计划中青年科技创新领军人才(2015年)
国家杰出青年科学基金获得者(2014年)
药明康德生命化学研究奖(2012年)
国务院政府特殊津贴获得者(2011年)
明治乳业生命科学奖(2010年)
中科院朱李月华优秀教师奖(2010年)
新世纪百千万人才工程国家级人选(2009年)
上海市浦江人才计划入选者(2008年)
中科院百人计划入选者(2006年)
美国白血病和淋巴瘤学会Special Fellow Award(2006年)

研究概述/Research Description:
  主要从事肿瘤疱疹病毒感染及致瘤机理研究,在卡波氏肉瘤疱疹病毒(KSHV)潜伏感染与致瘤机理研究方面做出了系统性、原创性的研究工作:曾揭示KSHV关键开关分子RTA的表达调控机机理,提出RTA-LANA负反馈调控工作模型,得到领域内的广泛认可,对阐明KSHV潜伏感染的形成机制有重要的指导意义;曾利用KSHV作为工作模型,率先发现病毒包装自身及宿主miRNA,不仅揭示了病毒粒子一种新的构成成分,也鉴定了胞外游离型miRNA的一种新的存在形式,具有重要的学术价值;曾阐明KSHV通过操控Notch及BMP等重要信号转导通路参与致瘤的新机制,为发展相关肿瘤有效的治疗手段奠定了重要基础。

代表性论文/Publications:

1. Wang X, Zou Z, Deng Z, Liang D, Zhou X, Sun R, Lan K*. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma. PLoS Pathog. 2017 Sep 28;13(9):e1006580.

2. Li G, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y, Lan K*, Deng Q*.
Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model. Hepatology. 2017 Jul 27. doi: 10.1002/hep.29406.

3. Lin X, Sun R, Zhang F, Gao Y, Bin L, Lan K*. The Latency-Associated Nuclear
Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency. J Virol. 2017 Aug 10;91(17). pii: e00806-17.

4. Zou Z, Meng Z, Ma C, Liang D, Sun R, Lan K*. Guanylate-Binding Protein 1
Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament. J Virol. 2017 Jul 27;91(16). pii: e00632-17.

5. Sun R, Tan X, Wang X, Wang X, Yang L, Robertson ES, Lan K*.Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues.PLoS Pathog. 2017 Jan 24;13(1):e1006167. doi: 10.1371/journal.ppat.1006167.

6. Li S, Hu H, He Z, Liang D, Sun R, Lan K*.Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.PLoS Pathog. 2016 Oct 19;12(10):e1005900. doi: 10.1371/journal.ppat.1005900.

7. Yang Y, Zhang J, Xia T, Li G, Tian T, Wang M, Wang R, Zhao L, Yang Y, Lan K*, Zhou W*.MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like?1 in hepatocellular carcinoma.Oncol Rep. 2016 Nov;36(5):2553-2562. doi: 10.3892/or.2016.5129.

8. Dong W, Chen Q, Hu Y, He D, Liu J, Yan H, Lan K*, Zhang C*.Epidemiological and clinical characteristics of respiratory viral infections in children in Shanghai, China.Arch Virol. 2016 Jul;161(7):1907-13. doi: 10.1007/s00705-016-2866-z.

9. Hu H, Dong J, Liang D, Gao Z, Bai L, Sun R, Hu H, Zhang H, Dong Y, Lan K*. Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor.J Virol. 2015 Nov 4;90(3):1158-68. doi: 10.1128/JVI.01392-15.

10. Jia B, Guo M, Li G, Yu D, Zhang X, Lan K*, Deng Q*.Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7.J Virol. 2015 Feb 15;89(4):2041-51. doi: 10.1128/JVI.03106-14. Epub 2014 Nov 26.

11. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K*. Kaposi's Sarcoma-Associated Herpesvirus-Encoded Replication and Transcription Activator Impairs Innate Immunity via Ubiquitin-Mediated Degradation of Myeloid Differentiation Factor 88.J Virol. 2015 Jan 1;89(1):415-27. doi: 10.1128/JVI.02591-14. Epub 2014 Oct 15.

12. Liang D , Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao S, Lan K*. Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis. PLoS Pathog.2014 Jul 10;10(7):e1004253.

13. Qi Z, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y, Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice. J Virol. 2014 Jul;88(14):8045-56. doi: 10.1128/JVI.01024-14.

14. Sun R, Liang D, Gao Y, Lan K*. Kaposi's Sarcoma-Associated Herpesvirus- Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency. J Virol. 2014 Jul 1;88(13):7331-7344.

15. Han J, Wang L, Liu J, Jin M, Hao F, Zhang P, Zhang Z, Wen D, Wu X, Liu G, Ji L, Xu D, Zhou D, Leng Q, Lan K*, Zhang C*. Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus. J Virol. 2014 Jun;88(11):6506-11.

16. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K*. Latency-Associated Nuclear Antigen of Kaposi Sarcoma-Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1. Cancer Res. 2014 Apr 1;74(7):2026-37.

17. Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML, Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection.J Virol. 2014 Mar;88(5):3004-15.

18. Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K*, Wei Y*.The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor β (TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia. J Biol Chem. 2013 Jan 18;288(3):1785-94.

19. Yang Y, Xia T, Li N, Zhang J, Yang Y, Cong W, Deng Q, Lan K*, Zhou W*. Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma. Protein Cell. 2013 Jan;4(1):71-81.

20. Lin X, Li X, Liang D, Lan K*. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirus virions. J Virol. 2012 Dec;86(23):12717-30.

21. Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES, Lan K*. Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-Jκ and Are Responsible for LANA-Mediated RTA Repression. J Virol. 2012 May;86(9):4956-69

22. Liang D, Lin X, Lan K*. Looking at Kaposi's Sarcoma-Associated Herpesvirus-Host Interactions from a microRNA Viewpoint. Front Microbiol. 2012 Jan 11;2:271. (Invited review)

23. Liu Y, Sun R, Lin X, Liang D, Deng Q, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5. J Virol. 2012 Feb;86(3):1372-81.

24. Li X, Liang D, Lin X, Robertson ES, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. J Virol. 2011 Sep;85(17):8606-15.

25. Lin X, Liang D, He Z, Deng Q, Robertson ES, Lan K*. miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA. PLoS One. 2011 Jan 20;6(1):e16224.

26. Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q, Lan K*. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε. Cell Res. 2011 May;21(5):793-806.

27. Wang X, He B, Zhang Z, Liu T, Wang H, Li X, Zhang Q, Lan K, Lu X, Wen H*. Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors. Virol J. 2010 Mar 17;7:62.

28. He Z, Liu Y, Liang D, Wang Z, Robertson ES, Lan K*. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol. 2010 Feb;84(4):2047-62.

29. Lan K, Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES. Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor. Cancer Biol Ther. 2009 Nov;8(22):2136-43.

30. Liu Y, Cao Y, Liang D, Gao Y, Xia T, Robertson ES, Lan K*. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. Virology. 2008 Oct 25;380(2):264-75.

31. Lan K, Verma SC, Murakami M, Bajaj B, Kaul R, Robertson ES. Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein. Proc Natl Acad Sci USA. 2007 Oct 9;104(41):16287-92.

32. Lan K, Choudhuri T, Murakami M, Kuppers DA, Robertson ES.Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro.J Virol. 2006 Jul;80(13):6411-9.

33. Lan K, Murakami M, Choudhuri T, Kuppers DA, Robertson ES. Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latency.Virology. 2006 Aug 1;351(2):393-403.

34. Lan K, Kuppers DA, Verma SC, Sharma N, Murakami M, Robertson ES. Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency. J Virol. 2005 Jun;79(12):7453-65.

35. Lan K, Kuppers DA, Robertson ES. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway. J Virol. 2005 Mar;79(6):3468-78.

36. Lan K,Kuppers DA, Verma SC, Robertson ES.Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency.J Virol. 2004 Jun;78(12):6585-94.